Abstract
Abstract
Approximately 5% to 10% of breast cancer cases and 11% to 18% of ovarian cancer cases are a result of a mutation in the BRCA1 and BRCA2 genes, known as hereditary breast and ovarian cancer (HBOC). An inherited mutation in either of these genes increases the probability of malignant transformation and cancer. This article provides a clinical overview of HBOC as well as risk-reduction measures that have the potential to decrease cancer development. The review of the literature highlights the psychological consequences, prophylactic measures, and potential postoperative complications. An examination of this public health issue increases our understanding of the challenges and decision-making processes faced by women with HBOC. Risk-reducing measures and effective strategies that can be implemented to assist these women and their families are discussed. Practice and research implications are outlined to improve health outcomes for these women. Patients’ rights as well as the costs associated with HBOC are also addressed.
