Abstract
Over the past 10 years, there have been significant advances in the diagnosis of lung cancer. Screening of high-risk patients with computed tomography scans and genomic biomarkers aid in the diagnosis of lung cancer patients at earlier stages. Historically, a diagnosis of lung cancer was made solely on histologic classification, usually when patients had advanced-stage disease. Diagnosis has become more precise and patient-centered with the incorporation of immunohistochemistry and genetic analysis for driver mutations utilizing tissue and liquid biopsies. Precise diagnostic classifications influence the prognosis, management, and outcomes of patients with lung cancer. This review will highlight key diagnostic elements essential for the multidisciplinary management of patients with lung cancer.