Volume 10, Number 2 (Mar 2019)

Editorial

The Benefits of Nuts for Cancer Prevention

According to a recent study, along with improving cardiovascular health, nuts could play a part in reducing the risk of colon cancer recurrence and death. Editor-in-Chief Pamela Hallquist Viale considers the preventative implications of ...

March 24, 2019

Quality Improvement

Impact of a Replacement Algorithm for Vitamin D Deficiency in Adult Hematopoietic Stem Cell Transplant Patients

Adults undergoing hematopoietic stem cell transplant (HSCT) are at risk for vitamin D deficiency. After HSCT, exposure to sunlight is restricted, and patients may experience poor nutrition and malabsorption from HSCT-related side effects...

March 24, 2019

Review Article

Adverse Effects of Virus-Specific T-Cell Therapy: An Integrative Review

Allogeneic hematopoietic stem cell transplant (HSCT) remains the mainstay in treating many hematologic malignancies. T-cell–depleted grafts designed to reduce graft-vs.-host disease (GVHD) may be complicated by severe viral infections th...

March 24, 2019

Grand Rounds

Advances in HER2-Positive Breast Cancer: Novel Therapies and Adverse Event Management

Abstract Although breast cancer is a heterogeneous disease, approximately 20% to 25% of patients diagnosed with breast cancer have amplification of the HER2 gene. The FDA approval of trastuzumab for the treatment of HER2-positive (HER2+...

March 24, 2019

Grand Rounds

Scalp Cooling: A Patient’s Experience

Case Study Ms. X is a 23-year-old female who presented to clinic with stage 2A endometrial cancer of the ovary. At her first visit, Ms. X was prescribed paclitaxel and carboplatin on day 1 for 6 cycles. During the visit, the nurse noted...

March 24, 2019

Considerations in Prescribing

Olaparib: A Novel Therapy for Metastatic Breast Cancer in Patients With a BRCA1/2 Mutation

Breast cancer is the most frequently diagnosed cancer in women globally. Genetic mutations can increase the risk of developing breast cancer. Inherited germline mutations in BRCA1 and BRCA2 tumor suppressor genes (gBRCAm) account for 5% ...

March 24, 2019

Tools and Technology

Use of the Distress Thermometer in Clinical Practice

Distress is experienced by many cancer patients, adversely affecting quality of life and cancer care. Although it is often manageable, it remains woefully underidentified and underreported. Distress can occur anytime during the cancer ex...

March 24, 2019

Diagnostic Snapshot

Diagnostic Snapshot: A Patient With Gastrointestinal Symptoms and Eosinophilia

Eosinophila has a number of possible causes and associated disorders; it requires selective testing directed at clinically suspected causes. Read through the history and physical examination, and put your skills to work to determine the ...

March 24, 2019