Translating Research Into Practice

Clinical Trial Design and Drug Approval in Oncology: A Primer for the Advanced Practitioner in Oncology

Sandra E. Kurtin,(1) PhD, ANP-C, AOCN®, and Rashida Taher,(2) MPH, PA-C

Evidenced-based practice requires timely and accurate integration of scientific advances. This presents a challenge for the oncology clinician given the robust pace of scientific discovery and the increasing number of new drug approvals ...

Secondary Analysis Research

Rita J. Wickham, PhD, RN, AOCN®

Abstract In secondary data analysis (SDA) studies, investigators use data collected by other researchers to address different questions. Like primary data researchers, SDA investigators must be knowledgeable about their research area to...

The Stepped-Wedge Trial Design: Paving the Way for Cancer Care Delivery Research

Ya-Huei Li, PhD, Elizabeth Mullette, RN, MSN, and Jeannine M. Brant, PhD, APRN, AOCN®, FAAN

Abstract Cancer care delivery research (CCDR) is an emerging field that investigates ways to optimally provide care for patients within complex health-care systems. Novel research designs are essential to efficiently study CCDR research...

The Challenges of Clinical Research in Rare Cancers: Bevacizumab Use in Low-Grade Serous Ovarian and Primary Peritoneal Cancers

There are challenges to conducting rare cancer clinical trials due to issues surrounding clinical trial design, patient recruitment, and analysis of the study outcomes. This article highlights the challenges of research and data analysis...

Liver Resection in Patients With Synchronous Colorectal Liver and Lung Metastases

Assessment of Overall Survival Benefits in Patients Undergoing Complete Hepatectomy for Synchronous Colorectal Cancer With Liver and Lung Metastases

Review of the New American Cancer Society Guidelines for Breast Cancer Screening for Women at Average Risk

When Should I Have a Mammogram? Recent Changes in ACS Mammography Guidelines: Implications for Practice

Overview of the CLEOPATRA Trial: Implications for Advanced Practitioners

An Introduction to Survival Statistics: Kaplan-Meier Analysis

Review of a Study on Late Referral to a Palliative Care Consultation Service: Length of Stay and In-Hospital Mortality Outcomes

Hospital-Based Palliative Care: Quality Metrics That Matter

Surgical Management of Colorectal Liver Metastases: Prognostic Indicators and the Impact of RAS Mutation Status

Molecular Profiling in Resectable Colorectal Liver Metastases: The Role of KRAS Mutation Status in Assessing Prognosis in the Preoperative Setting

Weighing the Benefits of Fish Oil for Patients With Prostate Cancer: A Subcohort Review From the SELECT Trial

Case-Cohort Conundrum: Fish or No Fish?

The Use of Calcium and Magnesium to Prevent Neurotoxicity in Patients Receiving Oxaliplatin

Calcium and Magnesium for Oxaliplatin-Induced Neurotoxicity: Issues in Study Design, Measurement, and Analysis

Oncology Communication Skills Training: Bringing Science to the Art of Delivering Bad News

Review of “Effect of communication skills training program for oncologists based on patient preferences for communication when receiving bad news: A randomized controlled trial” by Fujimori et al. (2014), Journal of Clinical Oncology, 32...

Understanding and Evaluating Survey Research

The Evolving Treatment Landscape for Metastatic Differentiated Thyroid Cancer

The Use of Meta-Analysis and Forest Plots to Examine and Display Data in Oncology Research

Clinical Management of Pancreatic Cancer

Use of Radiographic Criteria to Predict Outcomes Following Surgery for Pancreatic Cancer

Randomized Allocation to Treatment Groups and the Importance of Adjusting for Covariates

The Long and Short of Tamoxifen Therapy: A Review of the ATLAS Trial

Review of “Long term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial” by Davies et al. (2013), Lancet, 381, 805–816. ...

Assessment of Pathologic Response in Patients With Locally Advanced Rectal Cancer: Implications of the Park et al. Study

In a recent article in the Journal of Clinical Oncology, Park and colleagues reported on neoadjuvant treatment response as an early indicator of response for patients with rectal cancer. In this pair of articles, JADPRO contributors disc...

Locally Advanced Rectal Cancer: Does Assessment of Response After Neoadjuvant Chemoradiotherapy Impact Management?

Review of “Neoadjuvant treatment response as an early response indicator for patients with rectal cancer” by Park et al. (2012), Journal of Clinical Oncology, 15, 1770–1776. For another perspective on the Park et al. study, please see th...

Review of a Study of Duloxetine for Painful Chemotherapy-Induced Peripheral Neuropathy

In a recent issue of JAMA, Smith et al. evaluated the use of duloxetine in the treatment of patients with painful chemotherapy-induced peripheral neuropathy (CIPN). Here, JADPRO contributors give an overview of the Smith study and offer ...

Challenges in the Conduct of Research: Chemotherapy-Induced Peripheral Neuropathy

In a recent issue of JAMA, Smith et al. evaluated the use of duloxetine in the treatment of patients with painful chemotherapy-induced peripheral neuropathy (CIPN). Here, JADPRO contributors give an overview of the Smith study and offer ...

The Need for Communication Skills Training in Oncology

Communication between health-care professionals and their patients is an element that can make all the difference in how those patients navigate their cancer journey. In a 2011 issue of the Annals of Oncology, Barth and Lannen reported o...

Communication Skills Training: Using Evidence to Develop Programs That Improve Patient Outcomes

Communication between health-care professionals and their patients is an element that can make all the difference in how those patients navigate their cancer journey. In a 2011 issue of the Annals of Oncology, Barth and Lannen reported o...

New Cervical Cancer Screening Guidelines: Was the Annual Pap Too Much of a Good Thing?

With the advent of the Papanicolaou (Pap) test in 1945, mortality from cervical carcinoma declined more than 70%. An annual Pap smear was the recommended guideline for many years. But new guidelines recently released by the USPSTF recomm...

Guideline Evaluation

With the advent of the Papanicolaou (Pap) test in 1945, mortality from cervical carcinoma declined more than 70%. An annual Pap smear was the recommended guideline for many years. But new guidelines recently released by the USPSTF recomm...

Effects of Aspirin on Colorectal Cancer Related to Lynch Syndrome

This article is a review of “Long-term effects of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial” by Burn et al. (2011), Lancet, 378, 2081–2087. For another pers...

Aspirin and Decreased Colon Cancer Risk: Challenges Interpreting a Large Prospective Trial

In late 2011, Burn et al. published updated results on the CAPP2 trial in The Lancet. CAPP2 investigated the effects of daily aspirin on patients with Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer. The two relat...

Vitamin D in the Prevention of Aromatase Inhibitor–Induced Musculoskeletal Symptoms: Is It Ready for Practice?

Cholecalciferol and Cancer: Is It a Big D3-eal?

Acupuncture for the Management of Chemotherapy-Induced Peripheral Neuropathy

Threats to Validity in Retrospective Studies

A New Targeted Treatment for Lung Cancer Patients

Understanding Waterfall Plots

Fentanyl Nasal Spray: A New Option for Breakthrough Cancer Pain

Drug Approval: The Long and Bumpy Road to Market

How Is Your Pain…Management? Going Beyond the Fifth Vital Sign

Reliability and Validity: What’s the Difference and Why Does it Matter?

Overview of the AVADO and RIBBON-1 Clinical Trials

Throwing the Brake on the Drug Approval Train

Adding Early Palliative Care to
 Treatment of Non–Small Cell
 Lung Cancer

The Temel Paper on Palliative Care: When Scientific Rigor Is Not Enough

A New Immunotherapy for Melanoma?

The Hodi Paper: A Researcher’s View

Development and Use of Clinical Practice Guidelines

Translating Research Into Practice: Overview of Principles