Volume 14, Number 5 (Jul/Aug 2023)

Editorial

Providing Care During Cancer Drug Shortages

Drug shortages have become a global phenomenon, reaching an all-time high and affecting nearly every therapeutic area of medicine. Even short-term drug shortages cause deleterious effects in critical populations such as our patients with...

July 17, 2023

Research and Scholarship

Anti-Spike Antibody Responses in Allogeneic Stem Cell Transplant Recipients to Two Doses of COVID-19 mRNA Vaccination: A Retrospective, Single-Center Analysis

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients were excluded from the initial SARS-CoV-2 mRNA vaccination efficacy trials. Suboptimal vaccine responses have been reported in immunocompromised cohorts such as pa...

July 17, 2023

Research and Scholarship

Silent Conversations: Goals of Care and End-of-Life Quality in Relapsed High-Risk Leukemia

Background: Advanced practice providers (APPs) affect high-quality health care through leadership, evidence-based practice implementation, and quality improvement projects. When planning solutions to clinical problems, leadership must so...

July 17, 2023

Review Article

Quality of Life in Adult Cancer Patients With Underage Children: An Integrative Review

As many as 24.7% of cancer patients are also parents to children younger than 18 years of age. This population faces unique challenges, and quality of life in parental cancer patients has not been well studied. This integrative review as...

July 17, 2023

Review Article

Polycythemia Vera: Thinking Beyond the Hematocrit

Polycythemia vera is a Philadelphia chromosome–negative myeloproliferative neoplasm that results in increased myeloproliferation. It is a debilitating disease characterized by the overproduction of red blood cells, but it also can result...

July 17, 2023

Grand Rounds

Hyperammonemia Secondary to 5-Fluorouracil

5-fluorouracil (5-FU) is one of the most common adjuvant antineoplastic agents used in the treatment of localized and metastatic colon cancer. Frequent side effects of 5-FU include myelosuppression, mucositis, nausea, vomiting, and diarr...

July 17, 2023

Practice Matters

Managing Drug Interactions With Oral Anticancer Treatments

The use of oral anticancer treatments is widespread and vital to modern cancer treatment. Novel oral chemotherapy and targeted therapy treatments continue to receive US Food and Drug Administration approval every year, making knowledge o...

July 17, 2023

Diagnostic Snapshot

Can You Establish the Cause of This Patient’s Shortness of Breath?

Mr. B is a 56-year-old man diagnosed with metastatic HER2-positive gastroesophageal adenocarcinoma. He received front-line leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX) and trastuzumab for 10 months before restaging imaging reveal...

July 17, 2023